Treat twice daily until symptoms subside, or until infecting organism is completely eradicated as indicated by appropriate clinical or laboratory examination. To prevent reinfestation, treatment should be continued for the entire life cycle of the mite (approximately 21 days). SUROLAN Drops are appropriate for treating disease conditions such as: ● Otodectes cynotis (ear mite) infestation and associated otitis in cats, ● fungal infections when caused by M. canis in dogs and cats, ● non-specific dermatitis in dogs and cats. Shake well before use. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. (miconazole nitrate, polymyxin B sulfate, prednisolone acetate suspension). Otitis externa: The ear should be thoroughly cleaned and dried before the initiation of treatment, and examined to ensure the eardrum is intact. We comply with the HONcode standard for trustworthy health information -. The safe use of Surolan in animals used for breeding purposes, during pregnancy, or in lactating animals, has not been evaluated. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Studies have also indicated that SUROLAN Drops are effective in treating otoacariasis caused by Otodectes cynotis (ear mites) in cats. Surolan combines the antifungal and antibacterial activity of miconazole nitrate with the antibacterial activity of polymyxin B sulfate and the anti-inflammatory and antipruritic properties of prednisolone. 5 Hariharan H, McPhee L, Heaney S, Bryenton J. Antimicrobial drug susceptibility of clinical isolates of Pseudomonas aeruginosa. Select one or more newsletters to continue. Surolan is indicated for treating dogs and cats with otitic and dermal infections when caused by pathogens sensitive to miconazole nitrate or polymyxin B sulfate, and for the inflammation which often accompanies these conditions. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the Canadian product label or package insert. Medication is best accomplished using a cotton swab or finger cot. Cornelissen F, Van den Bossche H. Synergism of the antimicrobial agents miconazole, bacitracin and polymyxin B. Available for Android and iOS devices. Long-term use of topical and otic corticosteroids has been associated with adrenocortical suppression and iatrogenic hypoadrenocorticism in dogs. No data have been collected as to the safety of SUROLAN Drops in pregnant queens and bitches and, therefore, it should not be used in pregnant animals. Therapy should continue for 7 consecutive days. Before instilling any medication into the ear, examine the external ear canal thoroughly to be certain the tympanic membranes are not ruptured. Jpn J Vet Sci 1990;52(4):851-3. Sud IJ, Feingold DS. If hypersensitivity to any of the components occurs, treatment should be discontinued. 4. Topical antifungal, antibacterial and anti-inflammatory for dogs and cats. Surolan is appropriate for treating disease conditions such as: ● Otodectes cynotis (ear mite) infestation and associated otitis in cats, ● fungal infections when caused by M. canis in dogs and cats, ● non-specific dermatitis in dogs and cats. After 7 days, the veterinarian should evaluate the necessity to extend the treatment. 99 Subscribe to Drugs.com newsletters for the latest medication news, alerts, new drug approvals and more. Roll the bottle between both hands and shake well before use. For treatment of otoacariasis in cats it is recommended that excess debris be removed from the ear canals and the ears treated with 2-3 drops of SUROLAN twice daily. Keep out of reach of children. The usual dose for dogs of any weight is 5 drops placed into the ear canal 2 times a day and massage the ear. Each mL of SUROLAN Drops contains: miconazole nitrate 23 mg, polymyxin B sulfate 0.5293 mg, prednisolone acetate 5 mg. SUROLAN Drops combine the antifungal and antibacterial activity of miconazole nitrate with the antibacterial activity of polymyxin B sulfate and the anti-inflammatory and antipruritic properties of prednisolone. Action of antifungal imidazoles on Staphylococcus aureus. Massage the ear and the auditory canal gently but thoroughly to ensure proper distribution. You are seeing this ad based on the product’s relevance to your search query. If SUROLAN Drops are to be applied to extensive areas of the animal’s body surface, care should be exercised to avoid excessive oral ingestion. Subscribe to Drugs.com newsletters for the latest medication news, alerts, new drug approvals and more. Moreover, a synergistic interaction has been shown to exist between miconazole nitrate and polymyxin B sulfate against E. coli and S. aureus.4. We comply with the HONcode standard for trustworthy health information -, Direction and dosage information for Surolan. 4 Cornelissen F, Van den Bossche H. Synergism of the antimicrobial agents miconazole, bacitracin and polymyxin B. Avoid contact with eyes, since irritation may result. Clipping of hair around and over appropriate sites of infection should be done at the start of treatment and again as necessary. Data sources include IBM Watson Micromedex (updated 2 Nov 2020), Cerner Multum™ (updated 2 Nov 2020), ASHP (updated 23 Oct 2020) and others. The post-marketing adverse event reports for Surolan have shown that deafness and reduced hearing, usually of a transient nature, and topical hypersensitivity reactions such as erythema (or redness) and blisters on pinna, are very rarely reported (reported in less than 1 in 10,000 animals). Available for Android and iOS devices. Miconazole nitrate has been demonstrated to be effective in the treatment of canine and feline dermatomycoses when caused by Microsporum canis and has demonstrated in-vitro efficacy against a number of pathogenic fungi including M. gypseum, Trichophyton mentagrophytes, and T. interdigitale.1 Miconazole nitrate has also demonstrated in vitro efficacy against several species of yeast1 including Malassezia pachydermatis isolated from cases of canine otitis externa.2 Miconazole nitrate has also been shown to possess antibacterial activity against Gram-positive bacteria, including Staphylococcus aureus.1,3, The bactericidal properties of polymyxin B sulfate against Gram-negative bacteria, such as Escherichia coli4 and Pseudomonas aeruginosa,5 are well-established. The originating document has been archived. 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